Research Description

Role of Long Noncoding RNA-encoded Micropeptide in CF-Related Diabetes

Awards

• Predoctoral Training Grant in the Pharmacological Sciences (T32 GM144636), 2022-2024
• Teaching Intern, Experimental Biochemistry, University of Iowa, Spring 2021

Publications

• Sara C Sebag, Tate Neff, Qingwen Qian, Arvand Asghari, Zhuozhi Wang, Zeyuan Zhang, Mark Li, Meihua Hao, Vitor A Lira, Hongli Sun, Matthew J Potthoff, Ling Yang. Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline. bioRxiv [Preprint]. 2025 Sep 26:2025.07.01.662628. doi: 10.1101/2025.07.01.662628. PMID: 40631281; PMCID: PMC12236652

• Sara C Sebag*, Tate Neff*, Qingwen Qian, Arvand Asghari, Zhuozhi Wang, Zeyuan Zhang, Mark Li, Meihua Hao, Vitor A Lira, Hongli Sun, Matthew J Potthoff, Ling Yang. Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline. eLife. 2025 14:RP108145.  *Co-first authors

• Claflin KE, Flippo KH, Sullivan AI, Naber MC, Zhou B, Neff TJ, Jensen-Cody SO, Potthoff MJ. Conditional gene targeting using UCP1-Cre mice directly targets the central nervous system beyond thermogenic adipose tissues. Mol Metab. 2022 Jan;55:101405. doi: 10.1016/j.molmet.2021.101405. Epub 2021 Nov 26. PMID: 34844020; PMCID: PMC8683614

• Claflin KE, Sullivan AI, Naber MC, Flippo KH, Morgan DA, Neff TJ, Jensen-Cody SO, Zhu Z, Zingman LV, Rahmouni K, Potthoff MJ. Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity. Mol Metab. 2022 Oct;64:101564. doi: 10.1016/j.molmet.2022.101564. Epub 2022 Aug 6. PMID: 35944896; PMCID: PMC9403559.

• Acknowledged contributor, Sharon O. Jensen-Cody, Kyle H. Flippo, Kristin E. Claflin, Yavuz Yavuz, Sarah A. Sapouckey, Grant C. Walters, Yuriy M. Usachev, Deniz Atasoy, Matthew P. Gillum, Matthew J. Potthoff (2020). FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake. Cell Metabolism, 32(2), 273286.