Research Description

My research aims to utilize single-cell transcriptomics, optogenetic/chemogenetic techniques, and recombinase driver mice to characterize unique neuronal subpopulations within the hypothalamus and brainstem involved in the homeostatic regulation of appetite, thirst, and other autonomic functions.

Awards

• Fellowship Appointment on the Pharmacological Sciences Training Program (T32 GM144636), 2022-2024

• Dr. Lois Gehring Scholarship For academic and research excellence, 2022

Publications

• Ding X, Weber MA, Butler TC, Bova AS, Guerrero SG, Hunter CM, Cole RC, Stutt HR, McMurrin MS, Spicer MM, Conlon MM, Heiney SA, Kim Y, Resch JM, Narayanan NS. Distinct activity in prefrontal projections promotes temporal control of action. Proc Natl Acad Sci U S A. 2026 May 12;123(19):e2538059123. doi: 10.1073/pnas.2538059123. Epub 2026 May 6. PMID: 42090261; PMCID: PMC13167723.

• Li Y, Butler TC, Nardone S, Jacobs CL, Douglass AM, Madara JC, McDonough MC, Tao J, Lowenstein ED, Wang L, Pant D, Walker SJ, Wang A, Srinivasan H, Yang Z, Campbell JN, Tsai LT, Lowell BB, Resch JM. A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types. Cell Rep. 2026 Feb 24;45(2):116904. doi: 10.1016/j.celrep.2025.116904. Epub 2026 Jan 23. PMID: 41581146; PMCID: PMC13007250.

• Li Y, Butler T, Nardone S, Jacobs C, Madara J, McDonough M, Tao J, Lowenstein E, Wang L, Pant D, Walker S, Wang A, Srinivasan H, Yang Z, Campbell J, Tsai L, Lowell B, Resch J. A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types. 21 October 2025, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-7895391/v1]. 

• Ding, X., Weber, M.A., Butler, T.C., Bova, A.S., Guerrero, S., Hunter, C., Cole, R.C., Stutt, H.R., McMurrin, M., Spicer, M.M., Conlon, M.M., Heiney, S.A., Resch, J.M., Narayanan, N.S.  Diverse activity in prefrontal projtions promotes temporal control of action. bioRxiv [Preprint]. 2025 May 13:2025.05.12.653607. doi: 101/2025.05.12.653607, PMCID: PMC12132394

• Laule C, Guo DF, Zhao Y, Williams PA, Morgan DA, Rouabhi Y, McDonough M, Butler T, Resch J, Rahmouni K. The brainstem BBSome regulates glucose homeostasis and lean mass in a state-dependent manner. Mol Metab. 2025 Oct;100:102222. doi: 10.1016/j.molmet.2025.102222. Epub 2025 Jul 29. PMID: 40744313; PMCID: PMC12361606

• Butler, T.C., Zhang, J., Zhang, H., Ryu, S., & Greene, A.S.  Magnetic Patterning of Vorticella convallaria in a Microfluidic Device. J Eukaryot Microbiol. 67(6):687-690, 2020.  PMID: 32702141