Research Description

Uncovering the Source of Arachidonic Acid for Prostaglandin Synthesis During Drosophila Oogenesis

Awards

• Predoctoral Training Grant in the Pharmacological Sciences (T32 GM144636), 2022-2024
• Award winner 2024 3MT Showcase "Fueling the Fire: Fruit Flies and the Obesity-Cancer Connection"

Publications

• Thomalla JM, Giedt MS, White RP, Wipf IJ, Shipley A, Welte MA, Tootle TL. The lipid droplet protein Jabba promotes actin remodeling downstream of prostaglandin signaling during Drosophila oogenesis. bioRxiv [Preprint]. 2025 May 13:2025.05.09.653087. doi: 10.1101/2025.05.09.653087. Update in: Mol Biol Cell. 2025 Sep 1;36(9):ar105. doi: 10.1091/mbc.E25-05-0218. PMID: 40463279; PMCID: PMC12132472

• Thomalla JM, Giedt MS, White RP, Wipf IJ, Shipley A, Chen M, Welte MA, Tootle TL. The lipid droplet protein Jabba promotes actin remodeling downstream of prostaglandin signaling during Drosophila oogenesis. Mol Biol Cell. 2025 Sep 1;36(9):ar105. doi: 10.1091/mbc.E25-05-0218. Epub 2025 Jul 9. PMID: 40632522; PMCID: PMC12415609

• Wipf I, Anastas A, Daulton T, Nelson LL, Maity S, Malone K, Nguyen E, Ramos, R, Wright K, Xiong J, and Leatherman J.  Expression of ABC transporters in the Drosophila testis stem cell niche: Comparison of two approaches. Gene Expr Patterns. 2024 Dec 7;54:119386. doi: 10.1016/j.gep.2024.119386. Epub ahead of print. PMID: 39638273

• Liu S, Wipf I, Joglekar A, Freshly A, Bovee CE, Kim L, Richtsmeier SL, Peachee S, Kopriva S, Vikram A, Ladiki DE, Ilerisoy F, Ilerisoy B, Sagona G, Jun C, Giedt M, Tootle TL, Ankrum J, Imai Y. Lipid droplet protein Perilipin 2 is critical for the regulation of insulin secretion through beta cell lipophagy and glucagon expression in pancreatic islets. bioRxiv [Preprint]. 2024 Nov 18:2024.11.17.624030. doi: 10.1101/2024.11.17.624030. PMID: 39605485; PMCID: PMC11601606